MIT engineers stabilize RNA vaccines for room-temperature storage

MIT engineers used an AI algorithm to redesign lipid nanoparticles carrying RNA, enabling vaccines to remain stable at room temperature for up to a year and at 37°C for two months. Mouse tests showed immune responses matching Moderna-like vaccines. The breakthrough could expand global vaccine distribution.

The real beauty of this algorithm is that we can use it with small data sets. It's really hard to run thousands of experiments, so this algorithm allows us to more easily achieve formulations with features that we want, in this case, stability.